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P0300 on the 2019 GMC Sierra

The bulletins listed name this code in NHTSA's summary, or are about the same components. A bulletin or a recall listed here may apply to the model year. None of it is a diagnosis.

Nobody has written a description of this code yet.

Bulletins for this model year that name P0300
23-NA-0022024-07-22. Service bulletin. This technical bulletin provides repair information to correct a customer concern of Charge Air Cooler (CAC) Icing, Check Engine Lamp Illuminated, Possible P0299, P2227, and/or P0300 DTCs Set.
PIP5628G2023-09-18. Service bulletin. This Preliminary information communicates information that will need to be provided to TAC to aid in diagnosing if a vehicle comes in with misfire and DTC Codes P0300 - P0308 and/or P050D
PIP5628F2023-05-15. Service bulletin. This Preliminary information communicates information that will need to be provided to TAC to aid in diagnosing if a vehicle comes in with misfire and DTC Codes P0300 - P0308 and/or P050D
PIP5628E2023-03-13. Service bulletin. This Preliminary information communicates information that will need to be provided to TAC to aid in diagnosing if a vehicle comes in with misfire and DTC Codes P0300 - P0308 and/or P050D
23-NA-0022023-02-08. Service bulletin. This technical bulletin provides repair information to correct a customer concern of Charge Air Cooler (CAC) Icing, Check Engine Lamp Illuminated, Possible P0299, P2227, and/or P0300 DTCs Set.
PIP5628E2022-01-24. Service bulletin. This Preliminary information communicates information that will need to be provided to TAC to aid in diagnosing if a vehicle comes in with misfire and DTC Codes P0300 - P0308 and/or P050D
PIP5776C2021-05-17. Service bulletin. This Preliminary information communicates that a vehicle may exhibit a misfire condition resulting in misfire codes P0300-P308. Upon diagnosis it may be discovered the lifter has come apart. It is recommended to replace the lifter guide and the four lifters.
PIP5776B2021-04-19. Service bulletin. This Preliminary information communicates that a vehicle may exhibit a misfire condition resulting in misfire codes P0300-P308. Upon diagnosis it may be discovered the lifter has come apart. It is recommended to replace the lifter guide and the four lifters.
PIP5498M2020-09-14. Service bulletin. This Preliminary information communicates A vehicle may have a concern of DTC P050D setting along with a P0300 after a cold start up. White smoke and/or coolant odor may come from exhaust for an extended period of time at cold start as well. Cause Coolant getting into the cylinders, and provides direction for the repair.
PIP5298B2019-06-10. Service bulletin. This Preliminary Information communication provides information to the technician for a Service Engine Soon light with a Diagnostic Trouble code P0300 set. There may be a rough running engine associated with this concern. If service information diagnostics have been completed and there is still no trouble found, the technician is to inspect for a possible terminal tension concern on the ignition coil power feed for the cause of the rough running engine and or the P0300. For the Service Engine Soon light or traction control lamp concern check the X2 connector of the under hood fuse block for poor pin retention.

12 on file from NHTSA, as of 2026-10-19. See them in the bulletin list. A bulletin lists model years: read the document for which vehicles it concerns.