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P0300 on the 2000 GMC Sierra

The bulletins listed name this code in NHTSA's summary, or are about the same components. A bulletin or a recall listed here may apply to the model year. None of it is a diagnosis.

Nobody has written a description of this code yet.

Bulletins for this model year that name P0300
PIP5628G2023-09-18. Service bulletin. This Preliminary information communicates information that will need to be provided to TAC to aid in diagnosing if a vehicle comes in with misfire and DTC Codes P0300 - P0308 and/or P050D
PIP5628F2023-05-15. Service bulletin. This Preliminary information communicates information that will need to be provided to TAC to aid in diagnosing if a vehicle comes in with misfire and DTC Codes P0300 - P0308 and/or P050D
PIP5628E2023-03-13. Service bulletin. This Preliminary information communicates information that will need to be provided to TAC to aid in diagnosing if a vehicle comes in with misfire and DTC Codes P0300 - P0308 and/or P050D
PIP5628E2022-01-24. Service bulletin. This Preliminary information communicates information that will need to be provided to TAC to aid in diagnosing if a vehicle comes in with misfire and DTC Codes P0300 - P0308 and/or P050D
PIP4138L2017-08-15. Service bulletin. This Preliminary Information communication provides information to the technician about vehicles that have a Service Engine Soon Malfunction Indicator Lamp on, engine misfire, and/or engine noise. Technician may find Diagnostic Trouble Codes P0300-P0308. If published Service Information diagnostics does not isolate the cause of this concern technician should check for a worn camshaft lobe and/or lifter roller, a sticking valve, valve leakage, a broken valve spring, and a collapsed active fuel management lifter.
30812004-11-17. Service bulletin. SERVICE ENGINE SOON LIGHT AND P0300 WHEN TOWING, CRUISING UPHILL OR ON HARD ACCELERATION. *TT
30562004-11-17. Service bulletin. CHECK ENGINE LIGHT WITH A P0300 DUE TO 2-4 CYLINDERS MISFIRING ON THE SAME BANK OF THE ENGINE. *TT
30552004-10-14. Service bulletin. SERVICE ENGINE SOON LIGHT WITH A P0300 MISFIRE DUE TO MISFIRES MAINLY ON CYLINDER 7. *TT
006322004-07-06. Service bulletin. 4.3L L35 ENGINE-DIAGNOSTIC TROUBLE CODE P0300 BUT NO MISFIRE CAN FELT. *MJ
00149D2004-02-27. Service bulletin. MALFUNCTION INDICATOR LAMP ON WITH A P0300 SET AND A MISFIRE. VARIOUS MODELS INCLUDING 1996 - 1999 P32 MODELS. SIT BULLETIN 1416475. *TT

12 on file from NHTSA, as of 2026-10-19. See them in the bulletin list. A bulletin lists model years: read the document for which vehicles it concerns.