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P0300 on the 2018 Buick Regal

The bulletins listed name this code in NHTSA's summary, or are about the same components. A bulletin or a recall listed here may apply to the model year. None of it is a diagnosis.

Nobody has written a description of this code yet.

Bulletins for this model year that name P0300
18-NA-1152024-08-14. Service bulletin. This service bulletin provides inspection/diagnosis/correction information on a cold start misfire and/or rough idle and DTC P0300 that may also be set.
PIP5628G2023-09-18. Service bulletin. This Preliminary information communicates information that will need to be provided to TAC to aid in diagnosing if a vehicle comes in with misfire and DTC Codes P0300 - P0308 and/or P050D
PIP5628F2023-05-15. Service bulletin. This Preliminary information communicates information that will need to be provided to TAC to aid in diagnosing if a vehicle comes in with misfire and DTC Codes P0300 - P0308 and/or P050D
PIP5628E2023-03-13. Service bulletin. This Preliminary information communicates information that will need to be provided to TAC to aid in diagnosing if a vehicle comes in with misfire and DTC Codes P0300 - P0308 and/or P050D
18-NA-1152022-05-11. Service bulletin. This service bulletin provides inspection/diagnosis/correction information on a cold start misfire and/or rough idle and DTC P0300 that may also be set.
21-NA-0362022-03-30. Service bulletin. This service bulletin advises the technician of a diagnostic test for a possible issue with a damaged OCV solenoid that may cause an oil leak and misfire, illuminating the MIL and setting DTCs P0300, P0302 and/or P0305.
PIP5628E2022-01-24. Service bulletin. This Preliminary information communicates information that will need to be provided to TAC to aid in diagnosing if a vehicle comes in with misfire and DTC Codes P0300 - P0308 and/or P050D
PIP5628C2020-11-16. Service bulletin. This Preliminary information communicates information that will need to be provided to TAC to aid in diagnosing if a vehicle comes in with misfire and DTC Codes P0300 - P0308 and/or P050D
PIP5628B2020-06-15. Service bulletin. This Preliminary information communicates information that will need to be provided to TAC to aid in diagnosing if a vehicle comes in with misfire and DTC Codes P0300 - P0308 and/or P050D
PI1178F2019-03-25. Service bulletin. This preliminary informational bulletin provides repair information for a customer concern of an engine runs rough with the Check Engine Light (CEL) on/low compression on cylinder with misfire. A technician may find DTC P0300 set.

11 on file from NHTSA, as of 2026-10-19. See them in the bulletin list. A bulletin lists model years: read the document for which vehicles it concerns.